| 6/8/22 | Hereford |  | 3-3 | | Spennymoor | National League North | Edgar Street | |
| 13/8/22 | Spennymoor | | 15:00 | | AFC Telford United | National League North | The Brewery Field | |
| 16/8/22 | Spennymoor | | 19:45 | | Alfreton Town | National League North | The Brewery Field | |
| 20/8/22 | Leamington | | 15:00 | | Spennymoor | National League North | Your Co-Op Community Stadium | |
| 27/8/22 | Spennymoor | | 15:00 | | Darlington | National League North | The Brewery Field | |
| 29/8/22 | Bradford (Park Avenue) | | 15:00 | | Spennymoor | National League North | Horsfall Stadium | |
| 3/9/22 | Kidderminster Harriers | | 15:00 | | Spennymoor | National League North | Aggborough | |
| 10/9/22 | Spennymoor | | 15:00 | | Chester | National League North | The Brewery Field | |
| 13/9/22 | Spennymoor | | 19:45 | | Curzon Ashton | National League North | The Brewery Field | |
| 24/9/22 | Farsley Celtic | | 15:00 | | Spennymoor | National League North | The Citadel | |
| 27/9/22 | AFC Fylde | | 19:45 | | Spennymoor | National League North | Mill Farm | |
| 8/10/22 | Spennymoor | | 15:00 | | Buxton | National League North | The Brewery Field | |
| 15/10/22 | Kettering Town | | 15:00 | | Spennymoor | National League North | Latimer Park | |
| 22/10/22 | Spennymoor | | 15:00 | | Banbury United | National League North | The Brewery Field | |
| 25/10/22 | Spennymoor | | 19:45 | | Southport | National League North | The Brewery Field | |
| 29/10/22 | Scarborough Athletic | | 15:00 | | Spennymoor | National League North | Flamingo Land Stadium | |
| 5/11/22 | Spennymoor | | 15:00 | | Gloucester | National League North | The Brewery Field | |
| 8/11/22 | Chorley | | 19:45 | | Spennymoor | National League North | Victory Park | |
| 12/11/22 | Peterborough Sports |  | 15:00 | | Spennymoor | National League North | Lincoln Road | |
| 26/11/22 | Spennymoor | | 15:00 | | King's Lynn Town | National League North | The Brewery Field | |
| 3/12/22 | Brackley Town | | 15:00 | | Spennymoor | National League North | St James Park | |
| 6/12/22 | Spennymoor | | 19:45 | | Boston United | National League North | The Brewery Field | |
| 10/12/22 | Spennymoor | | 15:00 | | Hereford | National League North | The Brewery Field | |
| 13/12/22 | Alfreton Town | | 19:45 | | Spennymoor | National League North | The Impact Arena | |
| 26/12/22 | Blyth Spartans | | 15:00 | | Spennymoor | National League North | Croft Park | |
| 1/1/23 | Spennymoor | | 15:00 | | Blyth Spartans | National League North | The Brewery Field | |
| 7/1/23 | AFC Telford United | | 15:00 | | Spennymoor | National League North | New Bucks Head | |
| 14/1/23 | Spennymoor | | 15:00 | | Bradford (Park Avenue) | National League North | The Brewery Field | |
| 21/1/23 | Spennymoor | | 15:00 | | Leamington | National League North | The Brewery Field | |
| 28/1/23 | Darlington | | 15:00 | | Spennymoor | National League North | Blackwell Meadows | |
| 4/2/23 | Chester | | 15:00 | | Spennymoor | National League North | Deva Stadium | |
| 11/2/23 | Spennymoor | | 15:00 | | Kidderminster Harriers | National League North | The Brewery Field | |
| 18/2/23 | Spennymoor | | 15:00 | | Scarborough Athletic | National League North | The Brewery Field | |
| 21/2/23 | Southport | | 19:45 | | Spennymoor | National League North | Pure Stadium | |
| 25/2/23 | Gloucester | | 15:00 | | Spennymoor | National League North | Meadow Park | |
| 4/3/23 | Spennymoor | | 15:00 | | Chorley | National League North | The Brewery Field | |
| 7/3/23 | Boston United | | 19:45 | | Spennymoor | National League North | The Jakemans Community Stadium | |
| 11/3/23 | Spennymoor | | 15:00 | | Peterborough Sports | National League North | The Brewery Field | |
| 18/3/23 | King's Lynn Town | | 15:00 | | Spennymoor | National League North | The Walks | |
| 25/3/23 | Spennymoor | | 15:00 | | Brackley Town | National League North | The Brewery Field | |
| 1/4/23 | Buxton | | 15:00 | | Spennymoor | National League North | Tarmac Silverlands Stadium | |
| 7/4/23 | Spennymoor | | 15:00 | | AFC Fylde | National League North | The Brewery Field | |
| 10/4/23 | Curzon Ashton | | 15:00 | | Spennymoor | National League North | The Tameside Stadium | |
| 15/4/23 | Spennymoor | | 15:00 | | Kettering Town | National League North | The Brewery Field | |
| 22/4/23 | Banbury United | | 15:00 | | Spennymoor | National League North | Spencer Stadium | |
| 29/4/23 | Spennymoor | | 15:00 | | Farsley Celtic | National League North | The Brewery Field | |
