| Date | Home | Time/Result | Away | Competition | Venue | ||
|---|---|---|---|---|---|---|---|
| 14/8/21 | Boston United |  | 15:00 |  | Spennymoor | National League North | Jakemans Community Stadium |
| 21/8/21 | Spennymoor | | 15:00 |  | Southport | National League North | The Brewery Field |
| 28/8/21 | Leamington |  | 15:00 | | Spennymoor | National League North | Phillips 66 Community Stadium |
| 30/8/21 | Spennymoor | | 15:00 |  | York City | National League North | The Brewery Field |
| 4/9/21 | Hereford |  | 15:00 | | Spennymoor | National League North | Edgar Street |
| 11/9/21 | Spennymoor | | 15:00 |  | Farsley Celtic | National League North | The Brewery Field |
| 25/9/21 | Kettering Town |  | 15:00 | | Spennymoor | National League North | Latimer Park |
| 9/10/21 | Spennymoor | | 15:00 |  | AFC Telford United | National League North | The Brewery Field |
| 16/10/21 | Brackley Town |  | 15:00 | | Spennymoor | National League North | St James Park |
| 23/10/21 | Spennymoor | | 15:00 |  | Curzon Ashton | National League North | The Brewery Field |
| 26/10/21 | AFC Fylde |  | 19:45 | | Spennymoor | National League North | Mill Farm |
| 30/10/21 | Kidderminster Harriers |  | 15:00 | | Spennymoor | National League North | Aggborough |
| 6/11/21 | Spennymoor | | 15:00 |  | Alfreton Town | National League North | The Brewery Field |
| 13/11/21 | Bradford (Park Avenue) |  | 15:00 | | Spennymoor | National League North | Horsfall Stadium |
| 20/11/21 | Spennymoor | | 15:00 |  | Gateshead | National League North | The Brewery Field |
| 4/12/21 | Gloucester |  | 15:00 | | Spennymoor | National League North | New Meadow Park |
| 11/12/21 | Spennymoor | | 15:00 |  | Chester | National League North | The Brewery Field |
| 26/12/21 | Spennymoor | | 15:00 |  | Darlington | National League North | The Brewery Field |
| 28/12/21 | Blyth Spartans |  | 15:00 | | Spennymoor | National League North | Croft Park |
| 2/1/22 | Darlington | | 15:00 | | Spennymoor | National League North | Blackwell Meadows |
| 8/1/22 | Spennymoor | | 15:00 |  | Guiseley | National League North | The Brewery Field |
| 15/1/22 | Chorley |  | 15:00 | | Spennymoor | National League North | Victory Park |
| 22/1/22 | Spennymoor | | 15:00 |  | Boston United | National League North | The Brewery Field |
| 29/1/22 | Alfreton Town | | 15:00 | | Spennymoor | National League North | The Impact Arena |
| 5/2/22 | Spennymoor | | 15:00 | | Kidderminster | National League North | The Brewery Field |
| 12/2/22 | Spennymoor | | 15:00 | | Bradford (Park Avenue) | National League North | The Brewery Field |
| 19/2/22 | Gateshead | | 15:00 | | Spennymoor | National League North | International Stadium |
| 22/2/22 | Chester | | 19:45 | | Spennymoor | National League North | Swansway Chester Stadium |
| 26/2/22 | Spennymoor | | 15:00 | | Gloucester | National League North | The Brewery Field |
| 5/3/22 | Farsley Celtic | | 15:00 | | Spennymoor | National League North | The Citadel |
| 12/3/22 | Spennymoor | | 15:00 | | Kettering Town | National League North | The Brewery Field |
| 19/3/22 | AFC Telford United | | 15:00 | | Spennymoor | National League North | New Bucks Head |
| 22/3/22 | Spennymoor | | 19:45 | | AFC Fylde | National League North | The Brewery Field |
| 26/3/22 | Spennymoor | | 15:00 | | Brackley Town | National League North | The Brewery Field |
| 2/4/22 | Curzon Ashton | | 15:00 | | Spennymoor | National League North | Tameside Stadium |
| 9/4/22 | Spennymoor | | 15:00 | | Leamington | National League North | The Brewery Field |
| 15/4/22 | York City | | 15:00 | | Spennymoor | National League North | York Community Stadium |
| 18/4/22 | Spennymoor | | 15:00 | | Blyth Spartans | National League North | The Brewery Field |
| 23/4/22 | Southport | | 15:00 | | Spennymoor | National League North | The Pure Stadium |
| 30/4/22 | Spennymoor | | 15:00 | | Hereford | National League North | The Brewery Field |
| 2/5/22 | Guiseley | | 15:00 | | Spennymoor | National League North | Nethermoor Park |
| 7/5/22 | Spennymoor | | 15:00 | | Chorley | National League North | The Brewery Field |
