14/8/21 | Boston United |  | 1-2 |                                                      | Spennymoor | National League North | Jakemans Community Stadium | Watch |
21/8/21 | Spennymoor |                                                      | 3-2 |      | Southport | National League North | The Brewery Field | Watch |
28/8/21 | Leamington |    | 2-1 |                                                      | Spennymoor | National League North | Phillips 66 Community Stadium | Watch |
30/8/21 | Spennymoor |                                                      | 1-3 |    | York City | National League North | The Brewery Field | Watch |
4/9/21 | Hereford |    | 0-2 |                                                      | Spennymoor | National League North | Edgar Street | Watch |
11/9/21 | Spennymoor |                                                      | 6-0 |    | Farsley Celtic | National League North | The Brewery Field | Watch |
18/9/21 | AFC Fylde |      | 1-1 |                                                      | Spennymoor | Emirates FA Cup Second Round Qualifying | Mill Farm | Watch |
21/9/21 | Spennymoor |                                                      | 1-0 |      | AFC Fylde | Emirates FA Cup Second Round Qualifying Replay | The Brewery Field | Watch |
25/9/21 | Kettering Town |    | 1-2 |                                                      | Spennymoor | National League North | Latimer Park | Watch |
2/10/21 | Spennymoor |                                                      | 0-0 |      | Southport | Emirates FA Cup Third Round Qualifying | The Brewery Field | Watch |
5/10/21 | Southport |      | 3-2 |                                                      | Spennymoor | Emirates FA Cup Third Round Qualifying Replay | The Pure Stadium | Watch |
9/10/21 | Spennymoor |                                                      | 1-0 |    | AFC Telford United | National League North | The Brewery Field | Watch |
23/10/21 | Spennymoor |                                                      | 2-2 |    | Curzon Ashton | National League North | The Brewery Field | Watch |
26/10/21 | AFC Fylde |      | 2-0 |                                                      | Spennymoor | National League North | Mill Farm | Watch |
30/10/21 | Kidderminster Harriers |    | 4-0 |                                                      | Spennymoor | National League North | Aggborough | Watch |
6/11/21 | Spennymoor |                                                      | 0-2 |    | Alfreton Town | National League North | The Brewery Field | Watch |
9/11/21 | Brackley |    | 2-0 |                                                      | Spennymoor | National League North | St James Park | Watch |
13/11/21 | Bradford (Park Avenue) |    | 1-1 |                                                      | Spennymoor | National League North | Horsfall Stadium | Watch |
20/11/21 | Spennymoor |                                                      | 1-2 |     | Gateshead | National League North | The Brewery Field | Watch |
30/11/21 | Spennymoor |                                                      | 0-0 (3-1 on pens) |     | Chorley | FA Trophy Second Round | The Brewery Field | Watch |
4/12/21 | Gloucester |    | 2-0 |                                                      | Spennymoor | National League North | New Meadow Park | |
11/12/21 | Spennymoor |                                                      | 4-2 |    | Chester | National League North | The Brewery Field | Watch |
18/12/21 | Radcliffe FC |   | 0-1 |                                                      | Spennymoor | Buildbase FA Trophy Third Round | Neuven Stadium | |
22/12/21 | Gateshead |     | 0-5 |                                                      | Spennymoor | Durham Challenge Cup First Round | Gateshead International Stadium | |
26/12/21 | Spennymoor |                                                      | 1-1 |    | Darlington | National League North | The Brewery Field | Watch |
28/12/21 | Blyth Spartans |    | 3-1 |                                                      | Spennymoor | National League North | Croft Park | |
1/1/22 | Darlington |    | 1-1 |                                                      | Spennymoor | National League North | Blackwell Meadows | |
8/1/22 | Spennymoor |                                                      | 2-1 |    | Guiseley | National League North | The Brewery Field | Watch |
15/1/22 | Spennymoor |                                                      | 3-1 |   | Plymouth Parkway FC | Buildbase FA Trophy Fourth Round | The Brewery Field | Watch |
18/1/22 | Spennymoor |                                                      | 3-0 |   | Whickham FC | Durham Challenge Cup Second Round | The Brewery Field | |
22/1/22 | Spennymoor |                                                      | 1-1 |    | Boston United | National League North | The Brewery Field | Watch |
29/1/22 | Alfreton Town |    | 3-2 |                                                      | Spennymoor | National League North | The Impact Arena | Watch |
12/2/22 | Dagenham & Redbridge |   | 2-0 |                                                      | Spennymoor | Buildbase FA Trophy Fifth Round | Chigwell Construction Stadium | Watch |
19/2/22 | Gateshead |     | 2-1 |                                                      | Spennymoor | National League North | International Stadium | Watch |
22/2/22 | Chester |    | 0-2 |                                                      | Spennymoor | National League North | Swansway Chester Stadium | Watch |
23/02/22 | Spennymoor |   | 1-4 |   | Ryhope CW | Durham Challenge Cup | The Brewery Field | |
26/2/22 | Spennymoor |                                                      | 0-0 |    | Gloucester | National League North | The Brewery Field | Watch |
5/3/22 | Farsley Celtic |    | 1-2 |                                                      | Spennymoor | National League North | The Citadel | Watch |
8/3/22 | Chorley |     | 0-2 |                                                      | Spennymoor | National League North | Victory Park | Watch |
12/3/22 | Spennymoor |                                                      | 2-1 |    | Kettering Town | National League North | The Brewery Field | Watch |
15/3/22 | Spennymoor |                                                      | 0-0 |    | Kidderminster Harriers | National League North | The Brewery Field | Watch |
19/3/22 | AFC Telford United |    | 2-0 |                                                      | Spennymoor | National League North | New Bucks Head | Watch |
22/3/22 | Spennymoor |                                                      | 0-1 |      | AFC Fylde | National League North | The Brewery Field | Watch |
26/3/22 | Spennymoor |                                                      | 1-1 |    | Brackley Town | National League North | The Brewery Field | Watch |
2/4/22 | Curzon Ashton |    | 0-3 |                                                      | Spennymoor | National League North | Tameside Stadium | Watch |
5/4/22 | Spennymoor |                                                      | 0-2 |    | Bradford (Park Avenue) | National League North | The Brewery Field | Watch |
9/4/22 | Spennymoor |                                                      | 1-0 |    | Leamington | National League North | The Brewery Field | Watch |
15/4/22 | York City |    | 1-0 |                                                      | Spennymoor | National League North | York Community Stadium | Watch |
18/4/22 | Spennymoor |               |